16 May 2019 At this gestational age, the blood vessels in the brain are very fragile and easy to break when exposed to variations in blood pressure. The rupture of the blood vessels generally occurs in a small area of the brain called the germinal matrix , where new nerve cells are produced. This area is more fragile in premature babies and the likelihood of bleeding from it decreases after that age. The scan of choice for the diagnosis and monitoring of the haemorrhage is a transfontanellar ultrasound . Brain haemorrhage is classified in four grades based on its extent. A long-term prognosis for the lesions associated with a brain haemorrhage is difficult, mainly because: The brain is still developing; There is the possibility of some functional compensation. However, the most serious cases are usually associated with permanent disability. This article was written with the support of physicians and other clinical professionals from the Hospital da Luz network. The content published in the Health Guide is intended for the general public and is provided for informational and educational purposes only. It does not replace individual medical assessment, diagnosis, or personalized clinical advice from a qualified healthcare professional. The content is produced or reviewed by physicians and other healthcare professionals at Hospital da Luz and is based on the knowledge available at the time of publication or the most recent update, as indicated at the beginning of each item.