16 May 2019 It affects more than one million people in Portugal. However, only 20% of them will have significant symptoms during their lifetime. In some people, an association of multiple factors leads to small gallstones that cause symptoms. Among these factors are: A malfunction of the gallbladder; Abnormal bile composition; Diet; Genetic factors, such as certain types of anaemia, or others, Most people with gallstone symptoms undergo a cholecystectomy (surgical removal of the gallbladder). This article was written with the support of physicians and other clinical professionals from the Hospital da Luz network. The content published in the Health Guide is intended for the general public and is provided for informational and educational purposes only. It does not replace individual medical assessment, diagnosis, or personalized clinical advice from a qualified healthcare professional. The content is produced or reviewed by physicians and other healthcare professionals at Hospital da Luz and is based on the knowledge available at the time of publication or the most recent update, as indicated at the beginning of each item.