20 May 2019 Newborns are particularly susceptible to sepsis due to their immature immune systems . This risk is higher in the premature newborns. Newborns may be born already infected or develop the infection later. Sepsis in newborns is potentially serious, and always requires hospital admission. The fragility of the newborn’s skin constitutes an additional risk of infection. For premature newborns admitted to intensive care, it is necessary to have: Venous access with central lines for feeding and / or treatment; Endotracheal tubes for assisted ventilation. These can facilitate the entry of bacteria into the body, increasing the risk of infection. It is necessary to be particularly attentive to newborns because the signs of infection at this age are non-specific. In suspected infection, lab tests are performed to obtain information about: The severity of the infection; Guidance on therapy; Monitoring. This article was written with the support of physicians and other clinical professionals from the Hospital da Luz network. The content published in the Health Guide is intended for the general public and is provided for informational and educational purposes only. It does not replace individual medical assessment, diagnosis, or personalized clinical advice from a qualified healthcare professional. The content is produced or reviewed by physicians and other healthcare professionals at Hospital da Luz and is based on the knowledge available at the time of publication or the most recent update, as indicated at the beginning of each item.