16 May 2019 Phototherapy with ultraviolet B (UVB) radiation was the first to be used, but the latest narrow band equipment emits in the 311 nm band. The system causes the absorption of UVB radiation by chromophores in the cells and consequent oxidative stress with cell damage. The immunomodulatory effect is beneficial in the treatment of a number of conditions , especially: Psoriasis; Atopic eczema; Different forms of pruritus; Vitiligo; Alopecia areata; Certain skin lymphomas. Phototherapy is used with different protocols, depending on the patient’s condition situation and phototype . As a rule, it starts with three sessions per week. Radiation times with the latest equipment are quite short. Initially, they last little more than a minute, then increase on the basis of an assessment of progress before each treatment. Phototherapy is a safe , effective method, but safety measures are essential: Eye protection; Control of exposure times. This article was written with the support of physicians and other clinical professionals from the Hospital da Luz network. The content published in the Health Guide is intended for the general public and is provided for informational and educational purposes only. It does not replace individual medical assessment, diagnosis, or personalized clinical advice from a qualified healthcare professional. The content is produced or reviewed by physicians and other healthcare professionals at Hospital da Luz and is based on the knowledge available at the time of publication or the most recent update, as indicated at the beginning of each item.