13 May 2019 Cell death is a consequence of freezing and thawing of intracellular water. In addition to physical destruction, there are particularly important immune mechanisms in cryosurgery on malignant tumours . The degree of destruction depends on: Cooling speed Depth Number of cycles The cryogenic agent. As a rule, the agent is liquid nitrogen : With a boiling temperature of -195° C Applied as a spray or in closed systems. If indications and contraindications are respected, such as certain locations and darker skins, it can have interesting results in terms of efficacy and cosmetic effect. This article was written with the support of physicians and other clinical professionals from the Hospital da Luz network. The content published in the Health Guide is intended for the general public and is provided for informational and educational purposes only. It does not replace individual medical assessment, diagnosis, or personalized clinical advice from a qualified healthcare professional. The content is produced or reviewed by physicians and other healthcare professionals at Hospital da Luz and is based on the knowledge available at the time of publication or the most recent update, as indicated at the beginning of each item.