In the field of skin rejuvenation, and in particular facial skin rejuvenation, there are two important techniques that may be complementary: Botulinum toxin (Botox); Resurfacing with “ultrapulse” fractional carbon dioxide (CO2) laser. What is the role of Botulinum Toxin in skin rejuvenation? Botulinum toxin type A acts selectively on the neuromuscular junction. It has a paralysing effect, which means it decreases the strength of the muscles responsible for facial movements that lead to wrinkles. It is therefore most effective in the following areas: Upper third of the face; Forehead; Around the eyes (“crow’s feet”); Nasal pyramid. Botox is also useful for: Lip lines; Drooping mouth corners; Neck muscles. It is painless and has no side effects , provided it is applied by an experienced doctor. What is the role of ultrapulse fractional carbon dioxide laser in the field of skin rejuvenation? The ultrapulse fractional carbon dioxide laser is an ablative laser but, being fractional, it causes small cylindrical areas of thermal damage in a random, non-sequential pattern, surrounded by areas of intact tissue. Epithelisation then takes place in these areas, with a faster recovery. In addition to the improved texture and changed skin colour , the deep heat leads to the formation of new collagen - which may explain why the results last longer. The procedure requires topical anaesthesia and has an average recovery time of 1 week. Like all cosmetic treatments, it requires careful thought and, more than anything else, the provision of accurate information , taking into consideration the expectations of potential users. Full satisfaction with treatment results will only be possible if the client has realistic expectations. The content published in the Health Guide is intended for the general public and is provided for informational and educational purposes only. It does not replace individual medical assessment, diagnosis, or personalized clinical advice from a qualified healthcare professional. The content is produced or reviewed by physicians and other healthcare professionals at Hospital da Luz and is based on the knowledge available at the time of publication or the most recent update, as indicated at the beginning of each item.